TABLE II.
Parameter Values of SR Ca2+ Release Model
| Value
|
||||
|---|---|---|---|---|
| Parameter | Dog | Guinea-Pig | Units | Definition |
| β0 | 4.75 | 4.75 | ms | minimal value for βτ |
| Kβ | 0.28 | mmol/L | Half-saturation constant of Δβτ,CaMK | |
| Δβ0 | 1 | mmol/L | maximal CaMKII-dependent change for βτ | |
| αRel | κβτ | κβτ | mmol/L/ms | amplitude coefficient of IRel,∞ |
| KRel,∞ | 1 | 1 | mmol/L | Half-saturation constant of IRel,∞ |
| hRel | 8 | 9 | Hill coefficient of IRel,∞ | |
| hβ | 10 | Hill coefficient of Δβτ,CaMK | ||
| κ | 0.1125 | 0.125 | μF/μA | amplitude coefficient ofαRel |
| KRel,τ | 0.0123 | 0.0123 | mmol/L | Half-saturation constant of IRel,τ |
| τtr | 120 | 120 | ms | time constant of Itr |
| γCai | 0.341 | 1 | ms | Ca2+ activity coefficient |
| Īup,CamK | 0.9 | mmol/L | maximal CaMKII-dependent change of Iup | |