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. Author manuscript; available in PMC: 2009 Feb 15.
Published in final edited form as: Brain Res. 2007 Dec 23;1194:8–20. doi: 10.1016/j.brainres.2007.11.076

Figure 6.

Figure 6

Representative images with high magnification inserts of Griffonia simplicifolia isolectin B4 staining for microglia activity in the suprapyramidal blade of the dentate gyrus of wildtype (WT) and IL-1R1 knockout (IL-1R1−/−) mice. In saline controls, minimal staining of microglia with thin ramified processes was seen in both the WT (A) and IL-1R1−/− (B) mice. At 24 hrs post-TMT (2.0 mg/kg i.p.), increased staining of lectin+ microglia displayed ramified microglia with shortened, thick processes in both WT (C) and IL-1R1−/− (D) mice. By 72 hrs post-TMT, reactive and activated microglia with an amoeboid phagocytic morphology were evident in both WT (E) and IL-1R1−/− (F) mice. Scale bar = 100µm.