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. Author manuscript; available in PMC: 2008 Mar 24.
Published in final edited form as: J Med Chem. 2007 Jun 1;50(13):3138–3142. doi: 10.1021/jm061048b

Scheme 2.

Scheme 2

Synthesis of the Bismethylene Analogue 11: Route A, Catalytic Hydrogenation of (6 + 7) Mixture; Route B, Catalytic Hydrogenation of cis-8 (cDADAE)a

a Reagents and conditions: (a) H2/Pt/C 10%/MeOH, 48 h, rt; (b) NaOH (1 N, 3 equiv), 6 h, rt; (c) TFA/CH2Cl2 1:2, 1 h, rt.