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. Author manuscript; available in PMC: 2008 Mar 24.
Published in final edited form as: J Med Chem. 2007 Jun 1;50(13):3138–3142. doi: 10.1021/jm061048b

Table 2.

GTP Binding Assay

[35S]GTPγS bindinga
EC50 (nM) hDOR Emax(%)b EC50 (nM) hMOR Emax%b
cDADAE (8) 0.83 ± 0.05 121 2.35 ± 0.20 65
tDADAE (9) 0.88 ± 0.28 128 2.65 ± 0.45 70
a

Reference compound: [35S]GTP-γ-S.

b

Net total bound/basal binding × 100 ± SEM for compounds 8 and 9.