Table 1. HLA-A alleles and SJS/TEN with ocular complications.
|
HLA-A alleles |
Carrier frequency |
Allele frequency |
||||||
|
SJS (n=71) |
Normal (n=113) |
p-value (Χ2) |
Odds ratio |
SJS (n=142) |
Normal (n=226) |
p-value (Χ2) |
Odds ratio |
|
| *0101 |
0 |
0.035 |
0.16 |
- |
0 |
0.018 |
0.3 |
- |
| (0/71) |
(4/113) |
(0/142) |
(4/226) |
|||||
| *0201 |
0.268 |
0.221 |
0.47 |
- |
0.155 |
0.111 |
0.22 |
- |
| (19/71) |
(25/113) |
(22/142) |
(25/226) |
|||||
| *0206 |
0.423 |
0.15 |
0.00004 |
4.1 |
0.225 |
0.084 |
0.0001 |
3.2 |
| (30/71) |
(17/113) |
* |
(32/142) |
(19/226) |
* |
|||
| *0207 |
0.07 |
0.08 |
1 |
- |
0.035 |
0.04 |
1 |
- |
| (5/71) |
(9/113) |
(5/142) |
(9/226) |
|||||
| *0301 |
0.014 |
0 |
0.39 |
- |
0.007 |
0 |
0.39 |
- |
| (1/71) |
(0/113) |
(1/142) |
(0/226) |
|||||
| *1101 |
0.056 |
0.204 |
0.005 |
0.23 |
0.028 |
0.115 |
0.003 |
0.22 |
| (4/71) |
(23/113) |
(4/142) |
(26/226) |
* |
||||
| *2402 |
0.521 |
0.566 |
0.55 |
- |
0.296 |
0.332 |
0.47 |
- |
| (37/71) |
(64/113) |
(42/142) |
(75/226) |
|||||
| *2601 |
0.099 |
0.115 |
0.81 |
- |
0.049 |
0.062 |
0.65 |
- |
| (7/71) |
(13/113) |
(7/142) |
(14/226) |
|||||
| *2602 |
0.056 |
0.035 |
0.49 |
- |
0.028 |
0.018 |
0.49 |
- |
| (4/71) |
(4/113) |
(4/142) |
(4/226) |
|||||
| *2603 |
0.014 |
0.027 |
1 |
- |
0.007 |
0.013 |
1 |
- |
| (1/71) |
(3/113) |
(1/142) |
(3/226) |
|||||
| *3001 |
0.014 |
0.009 |
1 |
- |
0.007 |
0.004 |
1 |
- |
| (1/71) |
(1/113) |
(1/142) |
(1/226) |
|||||
| *3101 |
0.099 |
0.186 |
0.14 |
- |
0.049 |
0.093 |
0.16 |
- |
| (7/71) |
(21/113) |
(7/142) |
(21/226) |
|||||
| *3303 |
0.225 |
0.212 |
0.84 |
- |
0.113 |
0.111 |
0.95 |
- |
| (16/71) | (24/113) | (16/142) | (25/226) | |||||
HLA-A*0206 was strongly associated with SJS/TEN with ocular complications (carrier frequency: p<0.00005, corrected p value (Pc)<0.0005, OR=4.1; allele frequency: p<0.0005, Pc<0.005, OR=3.2). HLA-A*1101 was inversely associated (carrier frequency: p<0.01, Pc=0.07, OR=0.23; allele frequency: p<0.005, Pc<0.05, OR=0.22). SJS/TEN patients in this study consisted of 40 previously analyzed patients and 31 new patients. These results validate the strong association between HLA-A*0206 and SJS/TEN that we reported previously [13].