Table 4. HLA-DRB1 alleles and SJS/TEN with ocular complications.
|
HLA-DRB1 alleles |
Carrier frequency |
Allele frequency |
||||||
|
SJS (n=71) |
Normal (n=113) |
p |
Odds ratio |
SJS (n=142) |
Normal (n=226) |
p |
Odds ratio |
|
| *0101 |
0.113 |
0.097 |
0.81 |
- |
0.056 |
0.049 |
0.81 |
- |
| (8/71) |
(11/113) |
(8/142) |
(11/226) |
|||||
| *0401 |
0.028 |
0.018 |
0.64 |
- |
0.014 |
0.009 |
0.64 |
- |
| (2/71) |
(2/113) |
(2/142) |
(2/226) |
|||||
| *0403 |
0.028 |
0.053 |
0.71 |
- |
0.014 |
0.031 |
0.49 |
- |
| (2/71) |
(6/113) |
(2/142) |
(7/226) |
|||||
| *0404 |
0.014 |
0.009 |
1 |
- |
0.007 |
0.004 |
1 |
- |
| (1/71) |
(1/113) |
(1/142) |
(1/226) |
|||||
| *0405 |
0.197 |
0.248 |
0.43 |
- |
0.106 |
0.131 |
0.44 |
- |
| (14/71) |
(28/113) |
(15/142) |
(30/226) |
|||||
| *0406 |
0.028 |
0.062 |
0.49 |
- |
0.014 |
0.031 |
0.49 |
- |
| (2/71) |
(7/113) |
(2/142) |
(7/226) |
|||||
| *0407 |
0 |
0.035 |
0.16 |
- |
0 |
0.018 |
0.3 |
- |
| (0/71) |
(4/113) |
(0/142) |
(4/226) |
|||||
| *0410 |
0.028 |
0.018 |
0.64 |
- |
0.014 |
0.009 |
0.64 |
- |
| (2/71) |
(2/113) |
(2/142) |
(2/226) |
|||||
| *0701 |
0.014 |
0.009 |
1 |
- |
0.007 |
0.004 |
1 |
- |
| (1/71) |
(1/113) |
(1/142) |
(1/226) |
|||||
| *0802 |
0.113 |
0.062 |
0.27 |
- |
0.056 |
0.031 |
0.28 |
- |
| (8/71) |
(7/113) |
(8/142) |
(7/226) |
|||||
| *0803 |
0.239 |
0.133 |
0.06 |
- |
0.12 |
0.071 |
0.11 |
- |
| (17/71) |
(15/113) |
(17/142) |
(16/226) |
|||||
| *0901 |
0.301 |
0.31 |
1 |
- |
0.176 |
0.168 |
0.84 |
- |
| (22/71) |
(35/113) |
(25/142) |
(38/226) |
|||||
| *1001 |
0 |
0.009 |
1 |
- |
0 |
0.004 |
1 |
- |
| (0/71) |
(1/113) |
(0/142) |
(1/226) |
|||||
| *1101 |
0.07 |
0.027 |
0.26 |
- |
0.035 |
0.013 |
0.27 |
- |
| (5/71) |
(3/113) |
(5/142) |
(3/226) |
|||||
| *1201 |
0.028 |
0.062 |
0.49 |
- |
0.014 |
0.031 |
0.49 |
- |
| (2/71) |
(7/113) |
(2/142) |
(7/226) |
|||||
| *1202 |
0.085 |
0.035 |
0.19 |
- |
0.042 |
0.018 |
0.19 |
- |
| (6/71) |
(4/113) |
(6/142) |
(4/226) |
|||||
| *1301 |
0.014 |
0.009 |
1 |
- |
0.007 |
0.004 |
1 |
- |
| (1/71) |
(1/113) |
(1/142) |
(1/226) |
|||||
| *1302 |
0.169 |
0.195 |
0.66 |
- |
0.085 |
0.097 |
0.68 |
- |
| (12/71) |
(22/113) |
(12/142) |
(22/226) |
|||||
| *1401 |
0.028 |
0.053 |
0.71 |
- |
0.014 |
0.027 |
0.72 |
- |
| (2/71) |
(6/113) |
(2/142) |
(6/226) |
|||||
| *1403 |
0.042 |
0.062 |
0.74 |
- |
0.021 |
0.031 |
0.75 |
- |
| (3/71) |
(7/113) |
(3/142) |
(7/226) |
|||||
| *1405 |
0.056 |
0.062 |
1 |
- |
0.028 |
0.031 |
1 |
- |
| (4/71) |
(7/113) |
(4/142) |
(7/226) |
|||||
| *1406 |
0.014 |
0.018 |
1 |
- |
0.007 |
0.009 |
1 |
- |
| (1/71) |
(2/113) |
(1/142) |
(2/226) |
|||||
| *1501 |
0.183 |
0.106 |
0.14 |
- |
0.092 |
0.058 |
0.21 |
- |
| (13/71) |
(12/113) |
(13/142) |
(13/226) |
|||||
| *1502 |
0.127 |
0.186 |
0.31 |
- |
0.07 |
0.102 |
0.31 |
- |
| (9/71) |
(21/113) |
(10/142) |
(23/226) |
|||||
| *1602 |
0 |
0.035 |
0.16 |
- |
0 |
0.018 |
0.3 |
- |
| (0/71) | (4/113) | (0/142) | (4/226) | |||||
There was no significant association between HLA-DRB1 and SJS/TEN with ocular complications.