Table 5. HLA-DQB1 alleles and SJS/TEN with ocular complications.
|
HLA-DQB1 alleles |
Carrier frequency |
Allele frequency |
||||||
|
SJS (n=71) |
Normal (n=113) |
p |
Odds ratio |
SJS (n=142) |
Normal (n=226) |
p |
Odds ratio |
|
| *0201 |
0.014 |
0.009 |
1 |
- |
0.007 |
0.004 |
1 |
- |
| (1/71) |
(1/113) |
(1/142) |
(1/226) |
|||||
| *0301 |
0.254 |
0.212 |
0.52 |
- |
0.141 |
0.106 |
0.32 |
- |
| (18/71) |
(24/113) |
(20/142) |
(24/226) |
|||||
| *0302 |
0.169 |
0.177 |
0.89 |
- |
0.085 |
0.093 |
0.78 |
- |
| (12/71) |
(20/113) |
(12/142) |
(21/226) |
|||||
| *0303 |
0.296 |
0.354 |
0.41 |
- |
0.169 |
0.195 |
0.54 |
- |
| (21/71) |
(40/113) |
(24/142) |
(44/226) |
|||||
| *0401 |
0.197 |
0.239 |
0.51 |
- |
0.106 |
0.128 |
0.51 |
- |
| (14/71) |
(27/113) |
(15/142) |
(29/226) |
|||||
| *0402 |
0.056 |
0.053 |
1 |
- |
0.028 |
0.027 |
1 |
- |
| (4/71) |
(6/113) |
(4/142) |
(6/226) |
|||||
| *0501 |
0.113 |
0.097 |
0.81 |
- |
0.056 |
0.053 |
1 |
- |
| (8/71) |
(11/113) |
(8/142) |
(12/226) |
|||||
| *0502 |
0 |
0.08 |
0.01 |
0 |
0 |
0.04 |
0.01 |
0 |
| (0/71) |
(9/113) |
(0/142) |
(9/226) |
|||||
| *0503 |
0.085 |
0.062 |
0.57 |
- |
0.042 |
0.031 |
0.57 |
- |
| (6/71) |
(7/113) |
(6/142) |
(7/226) |
|||||
| *0601 |
0.352 |
0.274 |
0.26 |
- |
0.19 |
0.164 |
0.63 |
- |
| (25/71) |
(31/113) |
(26/142) |
(37/226) |
|||||
| *0602 |
0.155 |
0.106 |
0.33 |
- |
0.078 |
0.058 |
0.45 |
- |
| (11/71) |
(12/113) |
(11/142) |
(13/226) |
|||||
| *0603 |
0.014 |
0.009 |
1 |
- |
0.007 |
0.004 |
1 |
- |
| (1/71) |
(1/113) |
(1/142) |
(1/226) |
|||||
| *0604 |
0.169 |
0.195 |
0.66 |
- |
0.085 |
0.097 |
0.68 |
- |
| (12/71) | (22/113) | (12/142) | (22/226) | |||||
HLA-DQB1*0502 showed a tendency of negative association with SJS/TEN with ocular complications (carrier frequency: p<0.05, Pc=0.17, OR=0; allele frequency: p<0.05, Pc=0.19, OR=0). Although none of the 71 SJS/TEN patients and 10 of the 117 healthy volunteers (8.5%) had the HLA-DQB1*0502 allele, the correction of the p-value for the number of alleles detected (n=14) rendered the result not significant.