Table 6. Ethnic differences in the association of SJS/TEN with HLA.
|
Allele |
Japanese |
Caucasian [19] |
Taiwanese [18] |
|||
|
SJS |
Control |
SJS |
Control |
Carbamazepine induced SJS |
Control |
|
| A*0206 |
0.423 |
0.15 |
- |
(0 ~1.4%) |
- |
(3.1 ~24%) |
| B*1502 |
0 |
0 |
(0 ~0.2%) |
1 |
0.086 |
|
| B*4402 |
0.014 |
0 |
- |
(6.7 ~26.5%) |
- |
0 |
| B*4403 |
0.225 |
0.204 |
- |
(6.6 ~20.0%) |
- |
(0 ~2%) |
| DQB1*0601 | 0.352 | 0.274 | 0.17 | 0.03 | - | - |
Carrier frequency of SJS-associated alleles in Japanese and Caucasian. Data in parentheses are from “Allele Frequency in Worldwide Populations.”