Figure 11.

Hypothetical model. Incorporation of NF-YA (and probably with NF-YC) into mutant Htt aggregates causes reduction of functional NF-Y, resulting in suppression of HSP70/40 expression. Reduced expression of HSP70/40 would lead to acceleration of mutant Htt aggregation. This would also induce incorporation of some transcriptional factors into aggregates, which results in alteration of expression of their target genes. Expressions of NF-Y target genes other than HSP70 might be also affected. The reduction of HSP70/40 may result in reduction of their physiological functions, accelerating the aggregation formation and other pathological processes. These phenomenon might be cooperating together to modulate HD progression.