TABLE 2.
NEONATAL CS INHIBITS GENES ACTIVATED BY VIRAL DOUBLE-STRANDED RNA
| Gene Symbol | Fold Change | P Value | |||
|---|---|---|---|---|---|
| Activated by viral double-stranded RNA/induces type 1 IFN response | |||||
| Toll-like receptor 3 | TLR-3 | −3.4 | 0.005 | ||
| Retinoic –acid–inducible protein 1 | RIG-1 | −2.43 | 0.005 | ||
| Fas death domain–associated protein | DAXX | −1.88 | 0.005 | ||
| Melanoma differentiation associated gene 5 | MDA5 | −4.08 | 0.005 | ||
| DNA segment, Chr 11, Lothar Hennighausen 2, expressed | LGP2e | −11.63 | 0.005 | ||
| Interferon regulatory factor 7 | IRF-7 | −2.66 | 0.005 | ||
| Inhibits initiation of translation | |||||
| Interferon type I–induced and double- stranded RNA-activated kinase | PKR | −6.54 | 0.005 | ||
| Interferon-induced protein with tetratricopeptide repeats 1 | IFIT1/p56 | −19.84 | 0.005 | ||
| Interferon-induced protein with tetratricopeptide repeats 2 | IFIT2 | −4.69 | 0.005 | ||
| Interferon-induced protein with tetratricopeptide repeats 3 | IFIT3 | −13.74 | 0.005 | ||
| 2′-5′ oligoadenylate synthetase-like 2 | OASL2 | −6.15 | 0.005 | ||
| 2′-5′ oligoadenylate synthetase-like1 | OASL1 | −3.16 | 0.005 | ||
| 2′-5′ oligoadenylate synthetase-1A | OASLA | −4.79 | 0.005 | ||
| Adenosine deaminase RNA specific | ADAR | −5.5 | 0.005 | ||
| Z-DNA–binding protein 1 | ZBP1 | −12.47 | 0.005 | ||