Figure 1. Differential gene expression patterns in dengue disease.

mRNA levels (arbitrary units relative to β-2-microglobulin expression; presented as mean±SEM) from Indonesian children (n = 56) with severe dengue infections from day ‘Early’ (including admission samples of patients presenting >1 day before defervescence; n = 20), −1, 0, 1 and 5–8 from defervescence. Whereas IFNG and IL12A were up-regulated, a cluster of genes related to the NF-κB pathway was down-regulated, including NFΚB1, NFΚB2, IL1B and IL8.