Table 1. Chromosome 4q27 markers in UK genome wide association scan, and replication collections.

	UK genome wide association scan collection			Dutch collection			Irish collection			Meta-analysis
	Allele Freq. Cases	Allele Freq. Controls	P value1	Allele Freq. Cases	Allele Freq. Controls	P value1	Allele Freq. Cases	Allele Freq. Controls	P value1	Odds Ratio [95% CI]	P value1
	n=778	n=1422		n=508	n=929		n=483	n=560
rs6835946	30.3%	29.6%	0.63	25.1%	25.5%	0.81	31.4%	33.5%	0.32
rs11938795	21.2%	26.3%	0.00017
rs4374642	10.5%	8.4%	0.020	12.1%	8.4%	0.0015	8.3%	6.7%	0.17
rs13151961	12.6%	17.9%	5.2 × 10−6	12.2%	19.1%	2.2 × 10−6	14.8%	19.4%	0.0056	0.65 [0.58 - 0.73]	1.3 × 10−12
rs4505848	34.4%	32.3%	0.15	37.6%	34.9%	0.15	31.3%	27.8%	0.084
rs4288027	10.4%	8.4%	0.02
rs7683061	40.6%	38.0%	0.090
rs13119723	10.1%	15.8%	2.0 × 10−7	11.5%	16.4%	0.00042	12.8 %	16.2 %	0.030	0.66 [0.58 - 0.74]	4.8 × 10−11
rs11734090	21.5%	26.5%	0.00023
rs7699742	34.9%	32.2%	0.066
rs1127348	24.8%	21.6%	0.016	25.7%	24.0%	0.34	21.7%	16.9%	0.0053
rs7678445	9.9%	7.7%	0.013
rs7684187	25.2%	30.1%	0.00056
rs11732095	8.8%	8.6%	0.79	9.9%	9.1%	0.45	8.5%	7.7%	0.50
rs716501	34.8%	32.2%	0.087
rs10857092	5.2%	6.6%	0.069	7.8%	7.3%	0.60	7.0%	7.7%	0.53
rs6848139	10.2%	8.5%	0.050
rs6852535	29.7%	29.4%	0.84
rs12642902	28.5%	34.6%	3.3 × 10−5
rs6822844	12.6%	17.9%	4.6 x 10−6	12.4%	18.5%	2.1 × 10−5	14.2%	19.7%	0.0013	0.63 [0.57 - 0.71]	1.3 × 10−14
rs4492018	26.6%	26.5%	0.93	22.7%	23.1%	0.80	29.1%	30.2%	0.60
rs975405	38.6%	42.8%	0.0071	41.5%	43.3%	0.34	39.9%	43.9%	0.070
rs7682241	36.6%	34.4%	0.13
rs17005931	26.5%	26.2%	0.82
rs1398553	34.1%	30.6%	0.016	35.2%	32.6%	0.18	30.6%	25.7%	0.015
rs2893008	10.0%	8.0%	0.021	11.0%	7.4%	0.0011	7.3%	6.5%	0.50
rs6840978	16.3%	21.5%	3.8 × 10−5	15.2%	21.9%	2.0 × 10−5	19.2%	24.0%	0.0083	0.70 [0.63 - 0.78]	1.1 × 10−10

¹P values from χ² squared test of allele counts. All tests are two-tailed.