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. 2008 Jan 25;111(7):3884–3892. doi: 10.1182/blood-2007-11-125294

Figure 7.

Figure 7

β2M−/− and IAbβ−/− mCP-CML are resistant to CD8- and CD4-mediated GVL. (A) B6 mice were irradiated and reconstituted with TCD C3H.SW BM, wt B6 or β2M−/− mCP-CML, with or without C3H.SW donor CD8+ T cells. (B) B6 mice were irradiated and reconstituted with TCD 129 BM, wt B6 or IAbβ−/− mCP-CML, with or without purified 129 CD4+ T cells. (C) To determine whether the GVL resistance of IAbβ−/− mCP-CML is in the effector phase, irradiated B6 mice were reconstituted with TCD C3H.SW BM, wt mCP-CML, or IAbβ−/− mCP-CML or a mix of both wt and IAbβ−/− mCP-CML, with or without purified C3H.SW CD4+ T cells. Note that the only survivors were recipients of wt mCP-CML cells and donor C3H.SW CD4 cells, indicating that IAbβ−/− mCP-CML is GVL-resistant because of a defect in the effector phase. (D) Experimental design for panel C.