Fig. 7. EMSA of BTE oligonucleotides using CHO cell nuclear extracts.
EMSA was performed using 0.1 pmol of labeled BTE oligonucleotides and 10 μg of nuclear extracts obtained from CHO cells. Where indicated, competitor oligonucleotides (see “Experimental Procedures”) were added at a 10-fold molar excess of the labeled probe. In experiments involving antibodies, 2 μg of the stated antibody were added to the reaction. PI denotes pre-immune serum for GKLF. Super-shifted bands in lanes 7 and 8 are labeled with arrowheads. The positions of Sp1 and Sp3 in the DNA-protein complexes are indicated. The asterisks indicate either nonspecific complexes (since they competed poorly) or complexes containing as yet unidentified proteins.