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. 2007 Oct 12;407(Pt 3):435–450. doi: 10.1042/BJ20070579

Figure 5. Effect of CQ and metals on APP metabolism.

Figure 5

(A) APP-CHO cells were treated with CQ and Cu, Zn or Fe(II) for 6 h. CQ alone or CQ and Cu or Zn induced a decrease in cellular APP expression. Co-treatment with Fe(II) inhibited the loss of APP expression induced by CQ. (B) Treatment of APP-CHO cells with CQ or CQ plus Cu induced a reduction in secreted APP (sAPP) levels in conditioned medium after 6 h. The loss of sAPP corresponded to the loss of cellular APP. Treatment with CQ, Cu or CQ and Cu had no effect on expression of APP C-terminal fragments (CTFs).