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. 2007 Oct 12;407(Pt 3):435–450. doi: 10.1042/BJ20070579

Figure 8. Effect of JNK and MMP inhibitors on loss of cell adhesion and secreted Aβ levels in APP-CHO cells.

Figure 8

Cells were treated with 8HQ, NC or PDTC and Cu for 6 h in the presence or absence of 25 μM SP600125 (JNK inhibitor), 20 μM GM6001 (broad-spectrum MMP inhibitor), 25 μM MMP inhibitor-I (broad-spectrum MMP inhibitor), 10 μM MMP-2 inhibitor-I or 10 μM MMP-9 inhibitor-I. (A) Inhibition of JNK or MMPs blocked the loss of cell adhesion induced by each metal ligand complexed with Cu (*P<0.01). (B) Inhibition of MMPs prevented the loss of secreted Aβ-(1–40) induced by each metal ligand complexed with Cu (*P<0.01).