Table 1. List of metal ligands used to modulate cellular metal levels and Aβ metabolism.
# | Compound | Structure | Clog P (solubility) |
---|---|---|---|
8HQ derivatives | |||
1 | 5,7-diiodo-8HQ | 4.14 | |
2 | CQ | 3.75 | |
3 | 5,7-dichloro-8HQ | 3.34 | |
4 | 5-chloro-8HQ | 2.58 | |
5 | 8HQ | 2.08 | |
6 | 8HQ-2-sulfonic acid | −0.32 | |
7 | 4,8-dihydroxy-2-carboxylic acid-8HQ | −1.89 | |
Phenanthroline derivatives | |||
8 | BC | 6.83 | |
9 | BP | 5.83 | |
10 | 3,4,7,8-tetra-methyl-1,10-phen | 3.95 | |
11 | NC | 3.05 | |
12 | 2-chloro-1,10-phen | 2.81 | |
13 | 5-methyl-1,10-phen | 2.55 | |
14 | 1,10-phen | 2.05 | |
15 | BCS | 2.02 | |
16 | BPS | 1.03 | |
Sulfur compounds | |||
17 | PDTC | 1.71 | |
18 | D-penicillamine | −0.4 | |
Other compounds | |||
19 | TM | ND | |
20 | DFO | −0.5 |