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. 2007 Oct 12;407(Pt 3):435–450. doi: 10.1042/BJ20070579

Table 1. List of metal ligands used to modulate cellular metal levels and Aβ metabolism.

ND, not done as the Clog P calculation is not suitable for metal complexes. phen, phenanthroline.

# Compound Structure Clog P (solubility)
8HQ derivatives
1  5,7-diiodo-8HQ graphic file with name bic446i009.jpg 4.14
2  CQ graphic file with name bic446i010.jpg 3.75
3  5,7-dichloro-8HQ graphic file with name bic446i011.jpg 3.34
4  5-chloro-8HQ graphic file with name bic446i012.jpg 2.58
5  8HQ graphic file with name bic446i013.jpg 2.08
6  8HQ-2-sulfonic acid graphic file with name bic446i014.jpg −0.32
7  4,8-dihydroxy-2-carboxylic acid-8HQ graphic file with name bic446i015.jpg −1.89
Phenanthroline derivatives
8  BC graphic file with name bic446i016.jpg 6.83
9  BP graphic file with name bic446i017.jpg 5.83
10  3,4,7,8-tetra-methyl-1,10-phen graphic file with name bic446i018.jpg 3.95
11  NC graphic file with name bic446i019.jpg 3.05
12  2-chloro-1,10-phen graphic file with name bic446i020.jpg 2.81
13  5-methyl-1,10-phen graphic file with name bic446i021.jpg 2.55
14  1,10-phen graphic file with name bic446i022.jpg 2.05
15  BCS graphic file with name bic446i023.jpg 2.02
16  BPS graphic file with name bic446i024.jpg 1.03
Sulfur compounds
17  PDTC graphic file with name bic446i025.jpg 1.71
18 D-penicillamine graphic file with name bic446i026.jpg −0.4
Other compounds
19  TM graphic file with name bic446i027.jpg ND
20  DFO graphic file with name bic446i028.jpg −0.5