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. 2007 Oct 12;407(Pt 3):331–341. doi: 10.1042/BJ20070853

Figure 1. Functional domains of the cytomegalovirus DNA polymerase.

Figure 1

The conserved domains (I–VII) found in other type-B DNA polymerases are shown. These domains, as initially determined by Wang et al. [43], have been defined as follows according to the amino acid numbering of the enzyme: IV (379–421), II (696–742), VI (771–790), III (805–845), I (905–919), VII (962–970) and V (978–988). The consensus region of the DNA polymerase type-B family is also indicated (293–953). Additionally, the regions that have been shown to be critical for drug resistance are also shown along with the specific amino acids that have been shown to be associated with drug resistance.