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. 2007 Dec 26;36(4):1220–1226. doi: 10.1093/nar/gkm1133

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© 2007 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Formation of polyarginine(POA)/dsICL complex for silencing of ICL. (A) 10 mM acetate in medium gradually up-regulated the level of ICL transcripts during the 72 h period examined. (B) Formation of the dsRNA(ICL)/POA complex. To evaluate optimum complex formation, various concentrations of POA were mixed with a fixed concentration of dsRNA (lane 1, 100 ng of dsRNA only; lanes 2–11, 12.5, 25, 37.5, 50, 62.5, 75, 87.5, 100, 112.5 and 125 ng of POA mixed with 100 ng of dsRNA, respectively). As the POA concentration increased, dsRNA mobility was gradually retarded. The POA concentration in lane 8 was chosen as the most effective delivery-complex.