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. 1998 Jun 23;95(13):7766–7771. doi: 10.1073/pnas.95.13.7766

Table 1.

Activity ratios (REC) for PAR-APs and trypsin in the ISC, PAR2-KNRK, and aorta relaxation assays

Relative activity ratio (REC)*
assay
Agonist ΔISC PAR2KNRK Aorta relaxation
SL-NH2 1 1 1
tc-NH2 3.4  ± 0.4 0.8  ± 0.01 1.0
Cit-NH2 8.5  ± 0.4 460  ± 8 ND
Trypsin, ×103 7.4  ± 0.1 0.5  ± 0.02 0.5 ± 0.02
*

Activity ratios (REC) for each agonist, relative to the concentration of SL-NH2 (REC Created by potrace 1.16, written by Peter Selinger 2001-2019 1) causing an equivalent biological response, were calculated as described (18) from the concentration-effect curves shown in Fig. 3, according to the formula: REC = (concentration of agonist for a given response in the linear portion of its concentration-effect curve)/(concentration of SL-NH2 required to give the equivalent biological response). A value >1.0 designates an agonist with a potency lower than that of SL-NH2. Values for trypsin were multiplied by 103. Each value represents an average (± SEM) obtained from measurements done at three to seven levels of response along the concentration-effect curves for each agonist shown in Fig. 3. ND, not determined.