Table 5.
Enriched GO terms cross-referenced with occurrence of term and Alzheimer's in Entrez Gene and OMIM among human genes
| GO Term | |||||||
|---|---|---|---|---|---|---|---|
| Gene | Membrane (113 total) | Integral to membrane (39 total) | Endoplasmic reticulum | Estrogen receptor | MHC Class 1 protein complex | Sensory perception of smell | Chromosome |
| APH1A | X | X | 1p36-q31 | ||||
| APP | X | X | X | 21q21 | |||
| BCHE | X | 3q26 | |||||
| CASP7 | X | X | 10q25 | ||||
| CYP19A1 | X | X | 15q21 | ||||
| CYP46A1 | X | X | X | 14q32 | |||
| CYP7B1 | X | X | 8q21 | ||||
| DHCR24 | X | X | X | 1p33-31 | |||
| ESR1 | X | X | 6q25 | ||||
| ESR2 | X | 14q23 | |||||
| GNAS | X | X | 20q13 | ||||
| HFE | X | X | 6p21 | ||||
| HMOX1 | X | X | 22q13 | ||||
| HSD17B10 | X | X | X | Xp11 | |||
| ITGB1 | X | X | X | 10p11 | |||
| NCSTN | X | X | 1q22-23 | ||||
| OPRS1 | X | X | 9p13 | ||||
| PRNP | X | X | 20p13 | ||||
| PSEN1 | X | X | 14q24 | ||||
| PSEN2 | X | X | X | 1q31-42 | |||
| PSENEN | X | X | 19q13 | ||||
| STX8 | X | X | 17p12 | ||||
The terms ‘antigen presentation’, ‘MHC Class I receptor activity’, ‘photoreceptor cell maintenance’, ‘olfactory’ and ‘palmitoyl-CoA hydrolase activity’ did not return any human genes containing the GO term and ‘Alzheimer's’ from Entrez Gene. Only a partial listing for genes annotated with ‘membrane’ or ‘integral to membrane’ is shown. Genes that contain ‘Alzheimer’ in their OMIM reference are indicated in bold. Chromosomal regions for genes that co-localize with QTL included in this study are indicated in bold italics.