Table 7.
Enriched GO terms cross-referenced with occurrence of term body mass index or BMI in Entrez Gene and OMIM
| GO Term | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Metal ion binding | Nucleus | Regulation of transcription, DNA-dependent | Membrane | Transcription | Protein binding | Cell Adhesion | Serine-type endopeptidase inhibitor activity | Lipid binding | Chromosome |
| ACE | X | X | 17q23 | |||||||
| ADRB1 | X | X | 10q24-26 | |||||||
| ADRB2 | X | X | X | X | 5q31-32 | |||||
| ADRB3 | X | 8p11-12 | ||||||||
| AGT | X | 1q42-43 | ||||||||
| APOC3 | X | 11q23 | ||||||||
| BDNF | X | 11p13 | ||||||||
| CYP17A1 | X | 10q24 | ||||||||
| DGAT1 | X | 8q24 | ||||||||
| DRD4 | X | 11p15 | ||||||||
| ENPP1 | X | 6q22-23 | ||||||||
| ESR1 | X | X | X | X | X | X | X | 6q25 | ||
| IL1RN | X | 2q14 | ||||||||
| IL6 | X | 7p21 | ||||||||
| INS | X | 11p15 | ||||||||
| LEP | X | 7q31 | ||||||||
| LEPR | X | X | 1p31 | |||||||
| LPL | X | 8p22 | ||||||||
| MAOA | X | Xp11 | ||||||||
| NR3C1 | X | X | X | X | X | X | 5q31 | |||
| NTRK2 | X | X | 9q22 | |||||||
| PPARA | X | X | X | X | X | 22q13 | ||||
| PPARD | X | X | X | 6p21 | ||||||
| PPARG | X | X | X | X | X | 3p25 | ||||
| PPP1R3A | X | 7q31 | ||||||||
| SERPINE1 | X | X | 7q21-22 | |||||||
| SORBS1 | X | X | 10q23-24 | |||||||
| TFRC | X | 3q29 | ||||||||
| TGFBI | X | X | 5q31 | |||||||
| TNF | X | X | X | X | X | 6p21 | ||||
| TNFRSF1B | X | X | 1p36 | |||||||
| UCP1 | X | X | 4q31 | |||||||
| UCP3 | X | 11q13 | ||||||||
| VDR | X | X | X | X | X | 12q13 | ||||
The terms ‘homophilic cell adhesion’, ‘calcium-dependent cell–cell adhesion’, other more general related terms such as ‘calcium-dependent adhesion’, and ‘synaptogenesis’ did not return any hits when searched for co-occurrence with ‘body mass index’ or ‘BMI’ in Entrez Gene. Genes that contain ‘body mass index’ or ‘BMI’ in their OMIM reference are indicated in bold. Chromosomal regions for genes that co-localize with QTL included in this study are indicated in bold italics.