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. 2007 Dec 20;36(4):1113–1119. doi: 10.1093/nar/gkm1124

Figure 1.

Figure 1.

Design of the eight-stranded DNA cage. (a) Sequences of oligonucleotides OL1–OL8. Annealing regions are shown in color and non-annealing spacer regions in black. (b) Schematic illustration of assembly of the strands. The green region of one oligonucleotide base pairs with the green region of a partner oligonucleotide (example: green region of OL1 pairs with green region of OL2). The interrupted red region of one oligonucleotide pairs with the blue region of a partner oligonucleotide. This brings the ends of the first oligonucleotide together allowing covalent closure of the red region by ligation (example: OL1 forms a circle when the red region anneals with the blue region of OL7). Complete annealing of OL1–OL8 allows covalent closure of the structure. Oligo numbers are indicated in yellow circles.