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Effect of WTp53 on APE1 promoter reporter activity. (A) Basal promoter activity of APE1 promoter luciferase constructs containing −4500 or −1800 bp of APE1 promoter sequences linked to the luciferase gene. (B) p53(−/−) cells were transiently transfected with 0.5 μg of APE1 promoter–luciferase plasmid (−1800/+65) and WTp53 or control vector as before. Luciferase activity was measured 48 h after transfection as before; *P < 0.05.
