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. 2008 Jan 18;36(5):1464–1471. doi: 10.1093/nar/gkm1154

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — (a) Chemical structures of PNA and DNA. (b) Pseudo-complementary bases 2,6-diaminopurine (D) and 2-thiouracil (U_s) used in pcPNA. The D–U_s pair is destabilized by steric repulsion between the 2-amino group of D and the 2-S atom of U_s, although D–T and A–U_s pairs are sufficiently stable, as shown in (c) (32). (d) Chiral PNA units from N-(2-aminoethyl)-d-lysine, used for the promotion of double-duplex invasion in place of conventional PNA units.