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Adenovirus type 2 (Ad2) VA RNAI secondary structure and compensatory base pair mutations. Secondary structure model proposed following identification of two highly conserved complementary tetranucleotides (shown in outline typeface) and redrawing the Central Domain to base pair these sequences (9,14,20). Compensatory base pair modifications were made at six sites (1–6) distributed through the Terminal Stem, Central Domain and Apical Stem (see Table 1).
