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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Steroids. 2007 Sep 2;73(1):27–40. doi: 10.1016/j.steroids.2007.08.012

Table 3.

Variations1 in the External Loops of the α1-Subunit of the Na/K-ATPase of Sheep, Xenopus and Rat

M1-M2 External Loop
Sheep graphic file with name nihms-37606-t0010.jpg
Xenopus graphic file with name nihms-37606-t0011.jpg
Rat graphic file with name nihms-37606-t0012.jpg
M3-M4 External Loop
Sheep graphic file with name nihms-37606-t0013.jpg
Xenopus graphic file with name nihms-37606-t0014.jpg
Rat graphic file with name nihms-37606-t0015.jpg
M5-M6 External Loop
Sheep graphic file with name nihms-37606-t0016.jpg
Xenopus graphic file with name nihms-37606-t0017.jpg
Rat graphic file with name nihms-37606-t0018.jpg
M7-M8 External Loop
Sheep graphic file with name nihms-37606-t0019.jpg
Xenopus graphic file with name nihms-37606-t0020.jpg
Rat graphic file with name nihms-37606-t0021.jpg
M9-M10 External Loop
Sheep CPGMGAALRMYPLKP
Xenopus CPGMDVALRMYPLKP
Rat CPGMGAALRMYPLKP
1

Amino acids highlighted in red indicate residues identified as determinants of ouabain binding in the sheep enzyme (e.g. [13]), whereas those highlighted in green indicate residues that differ in Rat compared to sheep. Underlined sequences in C-terminal region of the M5-M6 loop indicate residues that are part of the transmembrane helix.