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. 2007;59:19–30. doi: 10.3114/sim.2007.59.03

Table 4.

A comparison between the different heterokaryon incompatibility and programmed cell death related genes in the two sequenced A. niger genomes (CBS513.88 and ATCC1015). If two proteins differ in size, the longer one is the basis for counting percentage of identities, similarities and gaps. Gaps are counted only in the homologous region.

Function Protein Type and size of difference Identities Gaps
Heterokaryon incompatibility genes (N. crassa & P. anserina)
HET-6 only HET domain motifs are slightly conserved - -
HET-C indel: 622 791/793 (99 %) 1/793
substitution: 196 (0 %)
UN-24 no difference (100 %) (0 %)
HET-C2 no difference (100 %)
HET-D / HET-E diverse proteins with WD40 repeats, but no remarkable similarity -
Suppressor genes (N. crassa)
TOL very diverse proteins, with conserved HET domain motifs - -
VIB-1 substitution: 195 585/586 (99 %) (0 %)
Incompatibility related genes (N. crassa & P. anserina)
HAM-2 substitution: 756 1066/1067 (99 %) (0 %)
PIN-C very diverse proteins, with conserved HET domain motifs - -
RNR-A no difference (100 %) (0 %)
IDI-6 / PSP 1st pair: indel: 534 531/535 (99 %)
(2 alleles) substitutions: 398, 525
2nd pair: substitutions: 398, 436-443, 450-459, 471-514 413/416 (99 %)
IDI-7 no difference (100 %)
Modifier genes (P. anserina)
MOD-D (2 alleles) Members of the two allele pairs are 100 % identical, between the pairs there are some difference: 1-167 variable part, 1-60 and 168-360 more conserved region.
MOD-E substitution: 244 672/702 (96 %) (0 %)
Programmed Cell Death genes (S. cerevisiae)
ATP4 no difference 100 % 0 %
CDC48 no difference 100 % 0 %
HEL 13 present only in CBS 513.88 - -
MCA1 / YCA1 1st pair 438/438 (100 %) (0 %)
(2 alleles)
2nd allele: indel region: 1-56, 75-104, 237, 443-447
subtitutions: 57-75, 105-106. 236, 440-442 2nd pair 341/441 (77 %) 1/333 (0 %)
NSR1 diverse proteins, with short conserved motifs - -
PPA1 no difference 100 % 0 %
SAR1 no difference 100 % 0 %
STM1 indel region: 8-13 297/303 (98 %) 6/303
(1 %)
TOR1 substitution: 16 2389/2390 (99 %) (0 %)