Figure 5. The impact of helminth inbreeding on the minimum number of microfilaria-positive hosts who should be sampled and the minimum number of microfilariae that should be genotyped to be 95% confident of detecting at least one rare allele.

A randomly mating population (, grey open squares) is compared to an inbred population (F_IS = 0.28 and , black diamonds). The underlying adult worm allele frequency of both populations is set at q^W = 0.05. Each data point represents 100,000 runs of the stochastic model generating microfilarial allele frequencies. The number of microfilariae analysed per host is proportional to host microfilaraemia.