Table 5.
Rank | Motif | Genes with Motif | Genes w/o Motif | Genes with Motif | Genes w/o Motif | Fisher's exact p-value | Hochberg adj p-value |
Top 1% Phylo Motifs | Genes Overexpressed in ER+ Tumors | Genes Overexpressed in ER- Tumors | |||||
1 | YACTGCCR | 17 | 113 | 2 | 143 | 0.0002 | 0.0423 |
2 | YYGCATGT | 10 | 120 | 1 | 144 | 0.0037 | 1.0000 |
3 | TGTANANAGA | 12 | 118 | 3 | 142 | 0.0142 | 1.0000 |
4 | TGCMNTAA | 26 | 104 | 14 | 131 | 0.0168 | 1.0000 |
5 | TGTGAA | 51 | 79 | 37 | 108 | 0.0196 | 1.0000 |
6 | TGTANNNTAG | 13 | 117 | 4 | 141 | 0.0214 | 1.0000 |
7 | TTTCTRNNAAA | 2 | 128 | 11 | 134 | 0.0219 | 1.0000 |
8 | AAGCACA | 19 | 111 | 9 | 136 | 0.0273 | 1.0000 |
9 | CTAKWTTT | 23 | 107 | 12 | 133 | 0.0286 | 1.0000 |
10 | TTTCTA | 52 | 78 | 41 | 104 | 0.0423 | 1.0000 |
Top 5% Phylo Motifs | |||||||
1 | WGCCTTA | 134 | 562 | 80 | 652 | < 0.0001 | 0.0031 |
2 | CTAKWTTT | 149 | 547 | 93 | 639 | < 0.0001 | 0.0032 |
3 | TGTGAA | 305 | 391 | 238 | 494 | < 0.0001 | 0.0034 |
4 | TATATTT | 210 | 486 | 149 | 583 | < 0.0001 | 0.0066 |
5 | TGTANNNTAG | 73 | 623 | 36 | 696 | 0.0001 | 0.0235 |
6 | TGTRNNNWATT | 148 | 548 | 101 | 631 | 0.0002 | 0.0571 |
7 | WRCCAAAA | 113 | 583 | 71 | 661 | 0.0003 | 0.0706 |
8 | TGTATANW | 218 | 478 | 168 | 564 | 0.0004 | 0.1144 |
9 | CTGTATWW | 134 | 562 | 91 | 641 | 0.0005 | 0.1248 |
10 | TGTRNTTT | 310 | 386 | 261 | 471 | 0.0007 | 0.1747 |