Table 2.

Recommended dose adjustments for patients with impaired renal function^a

Renal impairment	Dose
Mild	10 mg (full dose) every 24 h
(80 > CLcr ≥ 50 ml/min)
Moderate	5 mg every 24 h
(30 ≤ CLcr < 50 ml/min)
Severe	5 mg every 48 h
(CLcr < 30 ml/min, not requiring dialysis)
End-stage renal disease	5 mg three times a week after each dialysis
(CLcr < 30 ml/min, requiring dialysis)

^aRecommendations based on a pharmacokinetic study by Chen et al. [11]

CL_cr creatinine clearance

Table adapted from [11] © 2007 SAGE Publications. Adapted by permission of SAGE Publications, Inc.