TABLE 1.
HLA-A2-Restricted Activities of Patient’s TIL Clones and Cloids
| T-Cell Clones or Cloids from Patient
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| M26 | M-A1 | M18 | M-E5 | M-D2 | M-G5 | M8 | M37 | MR1 | ||
| Targets | HLA-A2 | (pg/mL IFN-γ) | ||||||||
| 624mel | + | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | 59 |
| 526mel | + | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | 0 | >1000 | 2 |
| F002Rmel | + | 1 | 0 | 24 | 0 | >1000 | >1000 | >1000 | >1000 | >1000 |
| 1102mel | + | >1000 | >1000 | 303 | >1000 | >1000 | 226 | 0 | >1000 | 11 |
| 624-28mel | − | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 2 | 7 |
| 397mel | − | 0 | 0 | 1 | 2 | 2 | 0 | 0 | 0 | 4 |
| 938mel | − | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 |
| T2 pulsed with | ||||||||||
| gp100:154–162 | + | 0 | 0 | 0 | >1000 | 3 | 0 | 0 | 0 | 0 |
| gp100:209–217 | + | >1000 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 |
| gp100:280–288 | + | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 3 |
| MART–1:27:35 | + | 0 | >1000 | >1000 | >1000 | 0 | 0 | 0 | 0 | 7 |
| TYR:368–376 | + | 0 | 0 | 761 | 0 | 0 | 0 | 0 | 0 | 11 |
| TRP-2:180–188 | + | 0 | 0 | 4 | 5 | >1000 | 1 | 0 | 0 | 4 |
| TRP-2-6b:403–411 | + | 0 | 2 | 7 | 9 | 5 | >1000 | 1 | 0 | 4 |
| NY-ESO-1:157–165 | + | 0 | 1 | 6 | 6 | 7 | 2 | >1000 | 0 | 5 |
| SOX10:331–340 | + | 0 | 1 | 7 | 8 | 7 | 4 | 0 | >1000 | 0 |
| T cell alone | 0 | 1 | 6 | 7 | 7 | 4 | 0 | 0 | 4 | |
| Antigen recognized | gp100 (209–217) | MART-1 | MART-1; Tyrosinase | gp100 (154–162); MART-1 | TRP-2 | TRP-2-6b | NY-ESO-1 | SOX10 | Unknown | |