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Exogenous IGF-II rescues myogenic differentiation from inhibition by active FoxO1. A, FoxO1–3A-ER cells were differentiated for 3 d in the presence or absence of 4-HT, with or without 150 ng/ml recombinant IGF-II. Myotube formation was assessed by MHC staining. B, A proposed model: active FoxO suppresses mTOR signaling and subsequent IGF-II production in a feedback loop that modulates myogenesis.
