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. 2007 Nov 26;149(3):955–961. doi: 10.1210/en.2007-0927

Figure 4.

Figure 4

A, Glucose tolerance test with 2 g/kg glucose in 2-month-old WT (circles, solid line), 2C (filled triangles, dashed line), OB (squares, solid line), and OB2C (filled diamonds, dashed line) mice. There was a significant effect of both htr2c and lep genotypes and a significant interaction between the two (htr2c, P = 0.008; lep, P < 0.0001; time, P < 0.0001; htr2c × lep, P = 0.03; htr2c × time, P = 0.7; lep × time, P < 0.0001; htr2c × lep × time, P = 0.9). B, Insulin tolerance test with 12 U/kg in 10-wk-old OB (squares, solid line) and OB2C (filled diamonds, dashed line) mice. There was a significant effect of htr2c (P = 0.008), time (P < 0.0001), and a significant interaction of htr2c × time (P = 0.03).