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. 2007 Nov 29;149(3):1329–1337. doi: 10.1210/en.2007-0235

Table 2.

Bone histomorphometric measurements in Ro1-expressing mice and littermate controls

Mice Ob.S/BS (%) Oc.S/BS (%) MS/BS (%) MAR (mcm/d) BFR (mcm/d)
Littermate controls, male 4.60 ± 0.96 0.22 ± 0.04 73.77 ± 3.43 0.5 ± 0.02 36.46 ± 1.44
Ro1 × Col I-2.3-tTA, male 4.49 ± 0.71 0.18 ± 0.04 67.08 ± 6.28 0.35 ± 0.04a 23.98 ± 3.83a
Littermate controls, female 18.68 ± 2.15 0.68 ± 0.10 82.65 ± 2.41 0.53 ± 0.04 44.32 ± 4.57
Ro1 × Col I-2.3-tTA, female 15.37 ± 1.54 0.89 ± 0.18 75.27 ± 2.47a 0.426 ± 0.04a 31.88 ± 2.47a

Ro1 expression was induced by doxycycline withdrawal at 4 wk of age. Analyses of osteoblast surface (Ob.S/BS) and osteoclast surface (Oc.S/BS) were performed in the distal femur of 12-wk-old mice, male (n = 13) and female (n = 14). Measurements of percent mineralizing surface (MS/BS), mineral apposition rate (MAR), and bone formation rate (BFR) were performed on tibias of 8-wk-old mice, male (n = 4) and female (n = 8). Mice were withdrawn from doxycycline at 4 wk of age. 

a

Significant increase or decrease in the parameter relative to the value in the corresponding littermate control group (P < 0.05). 

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