Figure 6.

NOD mice treated with Ex-4 2 μg twice daily for 26 wk have increased pancreatic insulin content and β-cell mass. Pancreatic insulin content (panels A and B) and β-cell mass (panels C and D) were measured at the end of the treatment period in all normoglycemic NOD mice that survived until the end of experiment 2 (panels A and C) and experiment 4 (panels B and D). Numbers above bar charts represent the number of animals. *, P < 0.05 Ex-4 vs. control (C) mice. Results displayed as mean ± sem.