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BVT.X significantly reduces food intake. Effects of BVT.X on acute intake of HFD in DIO (n = 11, average body weight 53 g; A) and ob/ob (n = 6, average body weight 51 g; B) mice. Saline (SAL) or BVT.X (20 or 60 mg/kg) were administered ip 45 min before the onset of the dark cycle. Total food intake was measured 6 h after injection (mean ± sem). Significant differences are indicated as follows: **, P < 0.01; ***, P < 0.001.
