Skip to main content
. 2007 Nov 26;149(3):1323–1328. doi: 10.1210/en.2007-1321

Figure 3.

Figure 3

Prolonged 5-HT2CR agonist infusion increases POMC mRNA expression and reduces percent body fat, body weight, and initial food intake. Obese ob/ob mice (n = 8, mean body weight 46 g) were treated with saline or BVT.X (60 mg/kg·d for 7 d, sc minipump). A, Prolonged BVT.X treatment increased POMC mRNA in the ARC, compared with saline treatment, as determined by densitometry analysis after ISHH with a 35S-labeled antisense POMC riboprobe. Prolonged BVT.X treatment significantly decreased percent body fat as determined by DEXA (B) and body weight (grams) (C), compared with pretreatment levels. D, BVT.X treatment decreased chow pellet intake on d 1 and 2, but no further significant differences were observed. Data are presented as mean ± sem. Significant differences are indicated as follows: *, P < 0.05; **, P < 0.01.