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. 2008 Mar 17;205(3):625–640. doi: 10.1084/jem.20071641

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Copyright © 2008, The Rockefeller University Press

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Figure 5. — Genome-wide microarray analysis of memory precursors and terminal effectors. Expression levels of mRNA were measured by microarray analysis of sorted P14 CD44^Lo naive cells, KLRG-1^Int and KLRG-1^Hi effector cells at day 4.5 p.i., and P14 memory cells at day 60 p.i. Gene ratios (fold change) represent the mean value of three to four independent hybridizations to Affymetrix microarrays. (A) Total number of transcripts differentially expressed (up- or down-regulated; twofold cutoff) between the indicated comparison groups is shown. (B) Relative intensities of all genes with a 2.5-fold cutoff in KLRG-1^Int and KLRG-1^Hi cells with respect to naive and memory populations are plotted as heat maps to depict the relationship between various populations. (C) All genes differentially expressed (twofold cutoff) between KLRG-1^Int and KLRG-1^Hi cells are functionally classified under broad categories based on information found in the Gene Ontology and Ingenuity Pathways databases and plotted as pie charts. (D) Enrichment profile of effector signature genes in KLRG-1^Hi versus KLRG-1^Int effector cells. GSEA of a set of genes corresponding to differentiated effectors (D8) in the rank-ordered list of genes differentially expressed between KLRG-1^Int versus KLRG-1^Hi effector cells is shown.