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. 2008 Mar 15;22(6):728–733. doi: 10.1101/gad.1641808

Figure 2.

Figure 2.

Experimental manipulation of miR-133 controls fin regeneration. (A) Design for RNA duplex (blue) and MO (red) electroporation studies. (B) Electroporation of miR-133 RNA duplex into the dorsal lobe (top, blue asterisk) slows regeneration in wild-type fins, as compared with a mutated miR-133 RNA duplex (bottom, black asterisk). (C) Electroporation of miR-133 MO into the dorsal lobe (top, red asterisk) enhances regeneration during Fgfr inhibition, as compared with a standard MO (bottom, black asterisk). (D,E) Quantification of average intrafin length ratios of injected versus uninjected fin lobes with miR-133 RNA duplex (D) or miR-133 MO (E). The injected:uninjected length ratio is significantly reduced by miR-133 duplex introduction, but significantly increased by miR-133 MO introduction (mean ± SEM; [*] P < 0.05, t-test; n = 10 per group).