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. 2008 Mar 15;22(6):770–785. doi: 10.1101/gad.1640908

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Figure 1. — Hic1 interacts with Ptch1 in the pathogenesis of medulloblastoma. (A) Log-rank Kaplan Meier analysis of tumor incidence in Ptch1^+/− Hic1^+/− mice versus Ptch1^+/− mice. (B) Hematoxylin/eosin staining of representative tumor from Ptch1^+/− Hic1^+/− animal. Bar, 20 μm. (C) Immunohistochemical stains for Synaptophysin (Syp), Glial fibrillary acid protein (Gfap), and Nestin (Nes) in a representative tumor, shown as DAB staining (brown), counterstained with hematoxylin (blue). Bars, 20 μm. (D) Semiquantitative Hh pathway expression profiling of 13 Ptch1^+/− Hic1^+/− and three Ptch1^+/− tumors. Mouse fetal cerebellum (FC) (Clontech) used as positive control. (Shh) Sonic hedgehog; (Ptch1) Patched1; (Smo) Smoothened; (Actb) β-Actin. (E) Nonquantitative Ptch1 PCR on genomic DNA from 13 Ptch1^+/− Hic1^+/− tumors.