Table 4.

Heparin found in gut and non-gut tissues following administration of 15 dosages of 1 mg per kg per 48 h by the oral or subcutaneous route

Stomach (μg gm−1)	Duodenum (μg gm−1)	Jejunum (μg gm−1)	Ileum (μg gm−1)	Colon (μg gm−1)	Lung (μg gm−1)	Liver (μg gm−1)	Urine (μg)a	Faeces (μg)a
Oral
9.0b	0.4	1.1b	5.9b,c	0.3	53.6c	3.4c	1.3	6.8
+21.9, −6.4	+0.2, −0.2	+0.6, −0.4	+5.6,−2.9	+0.1, −0.1	+75.1, −15.3	+16.4, −2.7	+0.4,−0.3	+1.0, −0.9
s.c.
1	0.2	0.2	0.4	0.4	97.4c,d	0.6	0.7	7
+3.0, −0.8	+0.1, −0.0	+0.1, −0.0	+0.2, −0.1	+0.1, −0.1	+73.9, −42.0	+1.1, −0.4	+0.2, −0.2	+8.4, −1.1
Control
1.4	0.5	0.6	1.4	0.5	1.9	0.1	0.5	3.5
+4.2, −1.0	+1.3, −0.4	+0.8, −0.4	+3.6, −1.0	+1.1, −0.3	+13.4, −1.6	+0.0, −0.0	+0.0, −0.0	+2.3, −1.4

Number in bold face are averages of 6–20 determinations. Light-face numbers are positive and negative standard errors after log transformation.

^aTotal micrograms for 24-h period

^bGreater than subcutaneous.

^cGreater than control.

^dGreater than oral administration.