Figure 4.

Effects of ODQ and zaprinast on the inhibitory effect of simvastatin on platelet aggregation. In the presence of L-arginine (100 μM), washed platelets were preincubated with simvastatin (60 μM) alone or in the presence of ODQ (1 μM) or zaprinast (5 μM) for 5 min, and then collagen (10 μg ml⁻¹) was added to trigger platelet aggregation. ^*P<0.05 and ^**P<0.01, as compared with the simvastatin and collagen-treated platelets. Percent inhibition of platelet aggregation is presented as the means±s.e.mean (n=5). ODQ, 1H-[1,2,4] oxadiazolo [4,3-a]quinoxalin-1-one.