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. 2008 Jan 21;153(6):1324–1330. doi: 10.1038/sj.bjp.0707675

Figure 3.

Figure 3

2-Aminoethoxydiphenyl borate (2-APB)-induced inhibition of transient receptor potential melastatin 2 (TRPM2) currents by cyclic ADPR (cADPR) plus heat was complete and reversible. (a–c) Representative traces of TRPM2 currents activated by cADPR in combination with heat in the presence and absence of flufenamic acid (FFA, 200 μM; a), N-(p-amylcinnamoyl)anthranilic acid (ACA, 20 μM; b) or 2-APB (100 μM; c). (d) Comparison of the TRPM2 current densities activated by cADPR in combination with heat in the presence of the indicated compounds. Numbers in parentheses indicate the number of cells tested. *P<0.01, **P<0.05.