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. 2008 Jan 21;153(6):1324–1330. doi: 10.1038/sj.bjp.0707675

Figure 5.

Figure 5

Inhibition of insulin secretion from rat isolated pancreatic islets by 2-aminoethoxydiphenyl borate (2-APB). (a) Heat (40 °C for 5 min)-evoked increase in insulin secretion was inhibited by 2-APB (100 μM). Data from the islets incubated at 29 °C with (+) or without (−) heat stimulation in the presence of 3.3 mM (G3.3) or 16.7 mM (G16.7) glucose. *P<0.01. (b) 2-APB significantly inhibited the insulin secretion in the presence or absence of exendin-4 (Ex-4, 10 nM) at 37 °C. *P<0.01, **P<0.05.