Table 1.

Comparison of the potencies of 2-APB in inhibiting a range of channels and proteins

Proteins	Concentration or IC50*	References
TRPC1	More than 80% inhibition at 80 μM	Delmas et al., 2002
TRPC3	Almost complete inhibition at 75 μM	Ma et al., 2000
TRPC5	19 μM*	Xu et al., 2005
TRPC6	10.4 μM*	Hu et al., 2004
TRPM2	0.82 μM* (ADPR+heat), 1.17 μM* (ADPR)
TRPM3	87.5% inhibition at 100 μM	Xu et al., 2005
TRPM7	178 μM*	Li et al., 2006
TRPM8	7.7 μM*	Hu et al., 2004
InsP3 receptor	42 μM*	Maruyama et al., 1997
Connexin36	3.0 μM*	Bai et al., 2006
Endogenous voltage-gated K+ channel (Limulus)	5 μM*	Wang et al., 2002

Abbreviations: ADPR, ADP-ribose; TRP, transient receptor potential; TRPC, TRP canonical or classical; TRPM, TRP melastatin. ^*Indicate IC₅₀ values but not significance as shown at the top of Table 1.