Table 5. DPB1 supertype-associated risk of BCP ALL in replicate series of cases compared with controls.
|
Series 1a
|
Series 2
|
Series 3
|
Series 4
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DPB1 supertype | OR | CI | P | OR | CI | P | OR | CI | P | OR | CI | P |
| DP2 | 1.6 | 1.2–2.1 | 0.001* | 1.8 | 1.3–2.4 | 0.003* | 1.6 | 1.1–2.1 | 0.007* | 1.9 | 1.3–2.9 | 0.006* |
| DP4 | 1.1 | 0.9–1.3 | 0.19 | 1.1 | 0.9–1.3 | 0.23 | 1.05 | 0.9–1.3 | 0.59 | 0.9 | 0.8–1.3 | 0.99 |
| DP6 | 1.3 | 0.9–1.7 | 0.17 | 1.2 | 0.8–1.7 | 0.48 | 1.3 | 0.9–1.8 | 0.26 | 1.02 | 0.6–1.8 | 0.99 |
| DP3 | 0.9 | 0.7–1.1 | 0.41 | 0.9 | 0.7–1.1 | 0.33 | 0.9 | 0.7–1.1 | 0.34 | 0.7 | 0.5–1.1 | 0.14 |
| DP8 | 3.0 | 1.3–6.8 | 0.01 | 3.1 | 1.3–7.6 | 0.02 | 3.4 | 1.4–8.2 | 0.01 | 4.4 | 1.6–12.5 | 0.03 |
| DP1 | 0.5 | 0.4–0.7 | <10−4* | 0.5 | 0.3–0.7 | <10−3* | 0.6 | 0.5–0.9 | 0.008* | 0.7 | 0.4–1.1 | 0.13 |
| Number= | 559 | 344 | 343 | 128 | ||||||||
a
Series 1: see Taylor et al (2002); series 2: 50% of series 1; series 3: 215 cases from series 1+128 cases from series 4; series 4: new cases in this study.
*Significant (P<0.05) after correction for six supertypes.