Table 6. Risk of BCP ALL, non-BCP leukaemia and paediatric solid tumours associated with DPB1 supergenotypes, compared with controls.
BCP ALL
|
Non BCP leukaemia
|
Solid tumour
|
|||||||
---|---|---|---|---|---|---|---|---|---|
Supergenotype | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P |
DP2/DP2 (GEG/GEG) | 0.9 | 0.4–1.9 | 0.99 | 0.9 | 0.3–2.8 | 0.99 | 1.02 | 0.4–2.4 | 0.99 |
DP2/DP4 (GEG/GKG) | 2.1 | 1.5–2.9 | 0.00004* | 1.6 | 0.9–2.7 | 0.14 | 1.1 | 0.7–1.8 | 0.7 |
DP2/DP6 (GEG/LED) | 2.5 | 1.0–5.8 | 0.06 | 2.5 | 0.8–7.7 | 0.3 | 1.5 | 0.5–4.5 | 0.6 |
DP2/DP3 (GEG/LKD) | 1.5 | 0.7–3.1 | 0.42 | 0.8 | 0.3–3.6 | 0.99 | 1.1 | 0.4–2.8 | 0.99 |
DP2/DP8 (GEG/GED) | 3.8 | 0.3–41.7 | 0.88 | 12.5 | 1.1–138.5 | 0.38 | — | — | — |
DP2/DP1 (GEG/GKD) | 1.1 | 0.5–2.7 | 0.96 | 0.6 | 0.1–7.9 | 0.99 | 0.9 | 0.3–2.6 | 0.99 |
DP4/DP4 (GKG/GKG) | 0.9 | 0.7–1.1 | 0.40 | 0.8 | 0.6–1.1 | 0.17 | 1.1 | 0.9–1.4 | 0.3 |
DP4/DP6 (GKG/LED) | 1.9 | 1.2–3.0 | 0.006 | 2.7 | 1.6–4.9 | 0.002* | 1.7 | 1.0–2.9 | 0.06 |
DP4/DP3 (GKG/LKD) | 1.1 | 0.8–1.4 | 0.80 | 1.2 | 1.2–14.6 | 0.1 | 1.1 | 0.7–1.5 | 0.8 |
DP4/DP8 (GKG/GED) | 2.7 | 0.9–7.1 | 0.08 | 1.9 | 0.1–15.3 | 0.99 | 0.6 | 0.1–2.9 | 0.7 |
DP4/DP1 (GKG/GKD) | 0.8 | 0.6–1.2 | 0.40 | 0.9 | 0.6–2.0 | 0.8 | 0.6 | 0.4–0.9 | 0.04 |
DP6/DP6 (LED/LED) | 0.6 | 0.2–1.7 | 0.48 | 1.1 | 0.3–4.0 | 0.99 | 1.7 | 0.7–4.3 | 0.4 |
DP6/DP3 (LED/LKD) | 0.5 | 0.2–1.1 | 0.09 | 1.1 | 0.04–3.1 | 0.67 | 0.2 | 0.07–0.81 | 0.02 |
DP6/DP8 (LED/GED) | — | — | — | — | — | — | 6.3 | 0.6–70.2 | 0.6 |
DP6/DP1 (LED/GKD) | 0.8 | 0.3–2.3 | 0.89 | 2.2 | 0.7–6.7 | 0.37 | 0.9 | 0.3–2.8 | 0.99 |
DP3/DP3 (LKD/LKD) | 0.7 | 0.4–1.2 | 0.23 | 0.8 | 0.4–1.8 | 0.76 | 1.1 | 0.6–1.9 | 0.9 |
DP3/DP8 (LKD/GED) | 3.3 | 0.8–12.8 | 0.16 | 2.5 | 0.4–15.0 | 0.95 | 2.1 | 0.4–10.5 | 0.7 |
DP3/DP1 (LKD/GKD) | 0.5 | 0.2–1.2 | 0.15 | 1.6 | 0.5–3.9 | 0.85 | 1.2 | 0.5–2.7 | 0.8 |
DP8/DP8 (GED/GED) | — | — | — | — | — | — | — | — | — |
DP8/DP1 (GED/GKD) | 3.8 | 0.3–41.7 | 0.88 | — | — | — | — | — | — |
DP1/DP1 (GKD/GKD) | 0.2 | 0.1–0.5 | 0.00004* | 0.4 | 0.1–1.06 | 0.06 | 0.8 | 0.4–1.5 | 0.6 |
Number= | 687 | 208 | 409 | ||||||
*Significant (P<0.05) after correction for 21 supergenotypes.