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Use-dependent block of wild-type hNav1.7 and hNav1.5 Na+ channels by 100 μM ranolazine. Repetitive pulses of + 50 mV for 10-ms at 5 Hz were applied in the presence of 100 μM ranolazine. Representative current traces of wild-type hNav1.7 (A) and hNav1.5 (B) were recorded and superimposed, with the label indicating the corresponding pulse number. The degree of the steady-state block of each isoform by ranolazine after repetitive pulses is given under Results.
