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. 2008 Feb 13;9:10. doi: 10.1186/1471-2121-9-10

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Copyright © 2008 Washington and Knecht; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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GFP-fusion proteins maintain their distinct localization in cells lacking endogenous filamin and α-actinin. The GFP probes were expressed in a cell line lacking both endogenous filamin and a-actinin and the localization examined. In each case, the results obtained were similar to the localization found when probes were expressed in wild-type cells. GFP-FLN maintains its cortical localization in the double mutant while GFP-αA is found in new protrusions but not in the cortex (Panels A and C). The same results were found for the ABD's of both proteins (Panels B and D).